Discussion Paragraphs 4 and 5
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I think it might be worth revisiting the ordering of these paragraphs (and, with reordering, light revisions). I read the fourth paragraph as having somewhat broader implications & how the data might be used to study pediatric cancer by integrating data modalities. The fifth paragraph is more technical on integrating new data. It might make more sense to lead with the technical paragraph (current 5) + the bits about integrating new datasets there and then touch a bit more on deconvolution/data modality integration for pediatric cancer research in the final paragraph (current 4). This isn't a strong preference, but it might help for target audiences.
E.g., in a final paragraph does it make sense to touch conceptually on deconvolution and then call out other resources (e.g., OpenPBTA) that might be available for integration.