Add AlphaMissense to the annotation sources
sorgoz opened this issue · 2 comments
AlphaFold's team just published a new tool - AlphaMissense:
https://www.science.org/doi/10.1126/science.adg7492
Calculated predictions are available at https://zenodo.org/record/8208688 (link taken from the original paper).
It would be great if you guys can add AlphaMissense to the sources for annotation. Thank you!
It is probably quite similar to PrimateAI-3D, developed by Illumina.
"I am very surprised that AlphaMissense was published in Science after PrimateAI-3D,” says Vasilis Ntranos, senior author of a third recent algorithm, which classified variants based strictly on a protein language model.
Source: AlphaFold-derived AI Predicts Genetic Mutations’ Impact, Chemical & Engineering News
Hello @sorgoz , @DarioS ,
thanks you for using Nirvana. Unfortunately, we are not providing AlphaMissense as a natively supported annotation source at this time.
Would you be open to using AlphaMissense via the CustomAnnotation feature provided https://illumina.github.io/IlluminaAnnotatorDocumentation/file-formats/custom-annotations/ ?
Thanks
Rajat