By hypothesizing bias in the Phase 3 trials of Pfizer-BioNTech COVID-19 vaccine based on their data, I challenged the significance of incidence of Bell's palsy in the vaccine group
- Implement the simulation for comparing different methods for calculating CI for the difference between two proportions (see
CI_for_proportions_methodrepo) - Write the abstract with new results
- Write work in two formats: A) Scientific paper format. B) Easy-reading article for medium.com
0. Official data about the vaccine and the trials
- fda (print version): https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=908ecbe7-2f1b-42dd-94bf-f917ec3c5af8&fbclid=IwAR3zspkyrP_mXIRNQCuWxW1mbj3vgPLA-ym8ryu5SdNvpBF5U96fgxnxSAc
- fda: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=908ecbe7-2f1b-42dd-94bf-f917ec3c5af8
- doi https://www.nejm.org/doi/full/10.1056/NEJMoa2034577
- doi (appendix): https://www.nejm.org/doi/suppl/10.1056/NEJMoa2034577/suppl_file/nejmoa2034577_appendix.pdf
1. Epidemology of Bell's palsy
- https://www.hindawi.com/journals/tswj/2014/801971/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701406/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220118/
2. Effect size for the difference between two proportions
- **https://www.who.int/medicines/technical_briefing/tbs/03-PG_Assessing-drug-efficacy_final-08.pdf ** (especially pages 23-27)
- https://ncss-wpengine.netdna-ssl.com/wp-content/themes/ncss/pdf/Procedures/PASS/Tests_for_Two_Proportions_using_Effect_Size.pdf
3. Other various statistical methods
- **https://online.stat.psu.edu/stat100/book/export/html/678 **
- https://people.richland.edu/james/lecture/m170/ch08-int.html
- https://handbook-5-1.cochrane.org/chapter_7/7_7_3_2_obtaining_standard_deviations_from_standard_errors_and.htm#:~:text=The%20standard%20deviation%20for%20each,should%20be%20replaced%20by%205.15.
- https://www.investopedia.com/ask/answers/042415/what-difference-between-standard-error-means-and-standard-deviation.asp
- **https://towardsdatascience.com/statistical-tests-when-to-use-which-704557554740 **
- https://bpsych.wordpress.com/2013/01/15/binomial-or-t-test/
- https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-019-6820-3#Tab1
4. About how to write the article
- embedding code in medium.com https://medium.com/pythoneers/9-different-ways-to-embedded-code-in-medium-9213cb4c0a2e#:~:text=Medium%20allows%20you%20to%20add,Windows%20%3A%20ctrl%2Balt%2B6
- math in medium.com (I guess I'll have to use characters with styling and pictures of LaTeX) https://medium.com/@tylerneylon/how-to-write-mathematics-on-medium-f89aa45c42a0
5. A concern of the vaccine causing Bell's palsy