RabadanLab/arcasHLA

Which genes does arcasHLA support?

slowkow opened this issue · 1 comments

IMGTHLA/alignments release 3.49.0 includes:

A,B,C,DMA,DMB,DOA,DOB,DPA1,DPB1,DQA1,DQA2,DQB1,DRA,DRB,E,F,G,HFE,MICA,MICB,TAP1,TAP2

Can we genotype all of these genes with arcasHLA by using the following command?

arcasHLA genotype R1.fq.gz R2.fq.gz -g A,B,C,DMA,DMB,DOA,DOB,DPA1,DPB1,DQA1,DQA2,DQB1,DRA,DRB,E,F,G,HFE,MICA,MICB,TAP1,TAP2

Or are we limited only to these genes?

A,B,C,DPB1,DQB1,DQA1,DRB1

Hi Kamil. Thank you for your interest in our tool. The choice of genes is limited to the ones listed in the file dat/info/parameters.json, which are currently as follows:

A,B,C,DMA,DMB,DOA,DOB,DPA1,DPB1,DQA1,DQB1,DRA,DRB1,DRB3,DRB5,E,F,G,H,J,K,L

If you do not supply the -g/--genes argument, all these genes will be considered by default.

We are planning to add the missing genes in a future release. (Similar issues: #60, #56, #38, #15.)