In this study, we developed a novel strategy for RA treatment, namely Antigen-Specific T Cell Vaccine (AgTCV). Subcutaneous administration of AgTCV significantly alleviated inflammation, cartilage damage, and bone erosion in RA. Through single-cell RNA sequencing analysis, we uncovered the previously overlooked role of neutrophils in immune tolerance remodeling.
ajinocean/AgTCV
We developed a specific Antigen-specific T Cell Vaccine (AgTCV) significantly alleviated inflammation, cartilage damage, and bone erosion in Rheumatoid Arthritis (RA) . Single-cell RNA sequencing analysis revealed the previously unrecognized role of neutrophils in remodeling the immune tolerance.
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