the choice of --peak
Closed this issue · 2 comments
zhoudreames commented
arangrhie commented
Hi @zhoudreames,
I'd say provide both haplotype assemblies and provide 43.3. If you only like to polish one haplotype, you could either provide vcf from one haplotype, or drop the filtered vcf from the other haplotype afterwards.
Merfin works best if the assembly matches the kmer spectrum as much as possible. Leaving one haplotype assembly out could cause potential haplotype switching.
Arang
zhoudreames commented
thanks~