An individual-based onchocerciasis dynamic model A individual-based, stochastic model of the Onchocerca volvulus
transmission system.
For full model details please see: Hamley JID, Milton P, Walker M,
Basáñez M-G (2019) Modelling exposure heterogeneity and density
dependence in onchocerciasis using a novel individual-based transmission
model, EPIONCHO-IBM: Implications for elimination and data needs. PLoS
Negl Trop Dis 13(12):
e0007557
The process overview within EPIONCHO-IBM, describing the steps through a
model run which reflect changes in the host/vector and parasite
life-cycle, is presented here:
Other publications utilizing and/or developing EPIONCHO-IBM include:
Hamley JID, Walker M, Coffeng LE, Milton P, de Vlas SJ, Stolk WA,
Basáñez MG. Structural Uncertainty in Onchocerciasis Transmission Models
Influences the Estimation of Elimination Thresholds and Selection of Age
Groups for Seromonitoring. J Infect Dis. 2020 Jun 11;221(Suppl
5):S510-S518.
Walker M, Hamley JID, Milton P, Monnot F, Pedrique B, Basáñez MG.
Designing antifilarial drug trials using clinical trial simulators. Nat
Commun. 2020 Jun
1;11(1):2685.
Hamley JID, Blok DJ, Walker M, Milton P, Hopkins AD, Hamill LC, Downs
P, de Vlas SJ, Stolk WA, Basáñez MG. What does the COVID-19 pandemic
mean for the next decade of onchocerciasis control and elimination?
Trans R Soc Trop Med Hyg. 2021 Mar
6;115(3):269-280.
Stolk WA, Blok DJ, Hamley JID, Cantey PT, de Vlas SJ, Walker M, Basáñez
MG. Scaling-Down Mass Ivermectin Treatment for Onchocerciasis
Elimination: Modeling the Impact of the Geographical Unit for Decision
Making. Clin Infect Dis. 2021 Jun 14;72(Suppl
3):S165-S171.
Walker M, Hamley JID, Milton P, Monnot F, Kinrade S, Specht S, Pedrique
B, Basáñez MG. Supporting Drug Development for Neglected Tropical
Diseases Using Mathematical Modeling. Clin Infect Dis. 2021 Sep
15;73(6):e1391-e1396. doi:
10.1093/cid/ciab350.
You can install the development version of EPIONCHO.IBM from
GitHub with:
# install.packages("devtools")# install.packages("remotes")remotes :: install_github(" mrc-ide/EPIONCHO.IBM" For a detailed practical guide please see the Installing and Running
EPIONCHO-IBM
vignette
