Setup an exome analysis pipeline

[eltonlaw]

Given some person's genome/sequencing reads

1. Align: Use a reference genome to find out the location of each read in the genome
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2. Variant calling: Get differences between target genome and the reference genome
3. Annotation: For each variant, search public data for its potential functional effects
4. Filter: Filter annotations for most likely to be disease causing
5. Prioritization: Supplement variant analysis with target's clinical history and family history.