Ver framework ligeros
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Buscando framework CSS ligeros encontré y recomiendo mirar Pure(jquery) y Picnic.
Resumen tras googlear:
http://www.hongkiat.com/blog/bootstrap-alternatives/
skeleton
cardinalcss
concisecss
powertocss
furtive
basscss
mueller
tuktuk
base
toast
http://stackoverflow.com/questions/9212536/alternatives-to-twitter-bootstrap
Blueprint.css
Zurb Foundation - comprehensive alternative, includes lots of templates
Skeleton - minimal option
Initialzr - includes a basic responsive template by default, but can also integrate with Bootstrap (mainly for integrating HTML5 Boilerplate with Bootstrap)
Flat UI Kit - based on Bootstrap, but lots of styles and colours in the 'flat' design.
Gumby - Responsive grid, uses Sass by default
Inuit - Based on Sass and uses OOCSS
http://www.monolinea.com/css-frameworks-comparison/
⋅⋅⋅ middleweights
Gumby
Groundwork
⋅⋅⋅ lightweights
Pure
Base
KubeCSS
He visto Pure CSS y Skeleton. MI enfoque es más hacia Skeleton, una base super ligera sobre la cual construir.