Reversed description of IEAA and EEAA in the vignette?

Hi,

If I understand correctly, the intrinsic changes in the methylome do not take into account the cell types, and it is what you've written in the function ageAcc2

methylclock/R/internals.R

Lines 21 to 22 in 325c73c

    
           mod.ieaa <- lm(y ~ age, data = df, na.action = "na.exclude") 
        
           mod.eeaa <- lm(y ~ ., data = df, na.action = "na.exclude")

So I think the descriptions of IEAA and EEAA in the vignette are reversed

methylclock/vignettes/methylclock.Rmd

Lines 36 to 37 in 325c73c

    
           - **IEAA** (Intrinsic Epigenetic Age Acceleration): Residuals obtained after regressing DNAmAge and chronological age adjusted by cell counts.   
        
           - **EEAA** (Extrinsic Epigenetic Age Acceleration): Residuals obtained after regressing DNAmAge and chronological age. This measure was also known as DNAmAge acceleration residual in the first Horvath's paper.

Best regards, Lijiao

Hi, thank you for using our package!

The code to get the IEAA and the EEAA is correct, as you comment, IEAA and EEAA descriptions are reversed in the vignette.
We have corrected and updated the vignette. Thanks for notifying us

Best,

Thanks for your work, I'll close this issue :)

	mod.ieaa <- lm(y ~ age, data = df, na.action = "na.exclude")
	mod.eeaa <- lm(y ~ ., data = df, na.action = "na.exclude")

	- IEAA (Intrinsic Epigenetic Age Acceleration): Residuals obtained after regressing DNAmAge and chronological age adjusted by cell counts.
	- EEAA (Extrinsic Epigenetic Age Acceleration): Residuals obtained after regressing DNAmAge and chronological age. This measure was also known as DNAmAge acceleration residual in the first Horvath's paper.