/HNSCC-Biomarker-Discovery

A repository for code related to my Dissertation, focused on feature engineering in large oncology data.

Primary LanguageR

HNSCC-Biomarker-Discovery

A repository that contains some code related to my Dissertation, focused on feature engineering in large oncology data.

DAE_preproc.R

Pre- and post-processing of DAE-constructed features.

TCGA_data_split.R

Holdout data selection using a continuous stratification approach.

data_split_simulations.R

Monte carlo simulations for empirical validation of the continuous stratification approach; including generation of simulated mRNAseq data, simulated outcomes using Weibull survival time generators, and evaluation of extra-sample performance estimation approaches with multiple survival model types and metrics.

This script is designed to run in parallel on SGE, so it is called with a command-line parameter indicating whether to: a) generate simulated data, b) run a specific simulation and write the results to a file, or c) aggregate output files of all completed simulations for analysis.

install_bioc_rtcga.R

Script for downloading TCGA-HNSC data.