MIGWAS for hg38 build?

[ruthchia]

Hi Saori,
I've used your tool for hg37 but wondering if you have updates suitable for hg38? I believe your current input miRNA files are based on hg37.

thanks!
Ruth

[saorisakaue]

Hi Ruth,

Thanks for your message and apologies that I did not notice this comment for a while.
The genome build hg19 is only affecting the Step 1, minimgnt.py part. Thus, if GWAS is based on hg38, you should just lift over it to hg19 (by tools like LiftOver) and run Step 1. The Step 2 is not dependent on the genome build once you convert GWAS statistics into gene- and miRNA- level P values (by running Step 1).
I hope this helps your analysis!

Best regards,
Saori