theislab/neural_organoid_atlas

Difficulty Annotating Brain Organoid Sample Using HNOCA Dataset

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Hello HNOCA Team,

I'm having trouble loading the HNOCA dataset into R for cell type annotation of my brain organoid samples. I've tried various packages (SingleR, BPCells), but the loading process doesn't complete, even after waiting 15 minutes. Is there a recommended method or package for efficiently loading the 40GB HNOCA dataset into R?

Thank you
Nicola