Quick restart with pressing LeftJoy on an Xbox controller
The Binding of Isaac: Repentance is out and mods are disabled currently. This program just spamming the 'R' while you press down the left joy on the controller.
https://github.com/1dle/tboi-restart/releases/download/v1.0/tboi-restart.exe
Connect the controller. Start the program and if it says the controller are found, then you can launch Binding of Isaac. You can swap the orders, it doesnt matter, but keep the program running.
You have to install vcredist (x86!!!): https://www.microsoft.com/en-us/download/details.aspx?id=48145