/CancerTargetPrediction

Code for the manuscript "Genome-wide investigation of gene-cancer associations for the prediction of novel therapeutic targets in oncology"

Primary LanguagePythonMIT LicenseMIT

Description

Official implementation for the paper "Genome-wide investigation of gene-cancer associations for the prediction of novel therapeutic targets", published in Nature Scientific Reports (link).

In this study we investigate how computational intelligence methods can be applied to predict novel therapeutic targets in oncology. We compared different machine learning classifiers applied to the task of drug target classification for nine different human cancer types.

Graphical summary

Summary of data reported in the paper

  • Training genes lists with labels: link
  • Model selection results: link
  • Multivariate feature importance analyses: link
  • Univariate feature importance analyses: link
  • Genome-wide predictions of final models for each cancer type: link
  • Literature evidence for the Top10 targets (via OpenTargets): link