What does it mean if a cell is undiff in its cell type annotation?
njbernstein opened this issue · 2 comments
njbernstein commented
What does it mean if a cell is undiff in its cell type annotation?
njbernstein commented
Does that mean it is an undefined progenitor?
calebweinreb commented
Yes, "undiff" just means that the cell wasn't confidently assigned to a
specific committed cell type. However the "undiff" cells comprise a
broad range of differentiation states, from putative HSCs to cells that are
well on their way toward a specific lineage and are already turning on
specific marker genes. In other words, it would be inaccurate to say that
they are "undifferentiated" in a formal biological sense.
…On Thu, Nov 18, 2021 at 6:19 PM njbernstein ***@***.***> wrote:
Does that mean it is an undefined progenitor?
—
You are receiving this because you are subscribed to this thread.
Reply to this email directly, view it on GitHub
<#9 (comment)>,
or unsubscribe
<https://github.com/notifications/unsubscribe-auth/ABO45MUTACKJDERZDWD3F4TUMWCZXANCNFSM5IKX5SPQ>
.
Triage notifications on the go with GitHub Mobile for iOS
<https://apps.apple.com/app/apple-store/id1477376905?ct=notification-email&mt=8&pt=524675>
or Android
<https://play.google.com/store/apps/details?id=com.github.android&referrer=utm_campaign%3Dnotification-email%26utm_medium%3Demail%26utm_source%3Dgithub>.