ProTINA (Protein Target Inference by Network Analysis) is a network-based analytical tool for identifying protein targets of compounds from gene transcriptional profiles. ProTINA scores proteins according to the enhancement or attenuation of the protein-gene regulatory interactions caused by a compound treatment. The magnitude of the scores indicates the degree of compound-induced alterations in the gene regulatory activity of a protein, while the sign of the scores indicates the direction of the alterations (positive: enhancement, negative: attenuation). In ProTINA, the protein targets of a compound are ranked according to the magnitudes of the protein scores.
MATLAB and R versions of ProTINA are available. Please refer to ProTINA manuscript for more detailed information.
For MATLAB distribution,
- MATLAB® R2014b or later
- GLMNET package
For R distribution,
- R software (>=3.4.1)
devtoolspackage in R
- MATLAB package: version 1.0 (10.10.2017)
- R package: version 1.0 (10.10.2017)
Redistribution and use in source and binary forms, with or without modification, are permitted provided agreeing to the Simplified BSD Style License (see more).
License (RTF, 2 KB)
Please refer to README for MATLAB and README for R.
This work has been supported by the ETH Zurich Research Grant.