It is hypothesized that certain alleles can have a protective effect not only when inherited by the offspring but also as non-inherited maternal antigens (NIMA). To estimate the NIMA effect, large samples of families are needed. When large samples are not available, we propose a combined approach to estimate the NIMA effect from ascertained nuclear families and twin pairs. We develop a likelihood-based approach allowing for several ascertainment schemes, to accommodate for the outcome-dependent sampling scheme, and a family-specific random term, to take into account the correlation between family members. This directory contains the R code implementation of this method.
BrunildaBalliu/NIMA
R implementation of Combined Joint Likelihood form http://onlinelibrary.wiley.com/doi/10.1002/gepi.21667/abstract;jsessionid=CA0F4965FBB79714946373653CB5B990.f03t03
R