Sex differences in functional brain organization

This is the repository for the publication:

Bianca Serio, Meike D. Hettwer, Lisa Wiersch, Giacomo Bignardi, Julia Sacher, Susanne Weis, Simon B. Eickhoff, & Sofie L. Valk, (2024) Sex differences in functional cortical organization reflect differences in network topology rather than cortical morphometry. Nature Communications, 15, 7714. https://doi.org/10.1038/s41467-024-51942-1.

Preprint version available here

Scripts

1. Preparing the data

calculate_fc_matrices_hcp_schaefer.ipynb computes functional connectivity matrices in Schaefer 400 parcellation from the HCP BOLD timeseries (averaged across 4 resting state sessions) at the individual level
p1_main_function.ipynb gets the functional connectivity matrices at the individual level
p1_main_microstructure.ipynb gets the microstructural intensity profile matrices at the individual level
p1_geodesic_distance.ipynb gets the geodesic distance of the functional connectivity profiles at the individual level
p1_connectivity_profiles_binary_matrices.py computing binary matrices for the Chi Square test of independence contingency tables
p1_connectivity_profiles_strength_fc_sub_level.py computes functional connectivity strength at the subject level for top 10% fucntional connections

2. Main analyses

p1_main.ipynb computes and visualizes main analyses
p1_main.R computes linear mixed effects models for main analyses
p1_connectivity_profiles_sex_diff.py runs Chi Square test of independence on contingency tables, testing for sex differences in the odds of connections belonging to the seed's top 10% functional connections at the individual level
p1_spin_permutation_lmer_within_between_network_dispersion.py spin permutation test to construct empirical null distribution of beta values for within and between network dispersion analyses

3. Functions

p1_myfunctions.ipynb contains functions used for main analyses

Data

Sample includes young adults (N=1000) from Human Connectome Project (HCP) S1200 release
Source Data.ods contains the source data used to make all figures included in the publication

Support

Please address any questions about the analyses or code to Bianca Serio

Research poster presented at:

Annual Meeting of the Organization for Human Brain Mapping (OHBM), Montreal 2023
Annual meeting of the Organization for the Study of Sex Differences (OSSD), Bergen 2024