NOTE: As of 24 Jun 2021, Chriona data has identified the mutation K417N mutation present in the Delta Plus variant (Pango AY.1) with ~24 points. Since this data was taken on 23 May 2021, newer mutations can only be screened with newer data from GISAID/NCBI.
Current SARS-Cov-2 variants and lineages are identified by PANGOLIN.
Emerging variants show resistance against vaccines previously produced, with neutralising effects.
Chirona attempts to find hotspots of mutations in SARS-CoV-2 Pango lineages and generate permutations of sequences that can adapt to said mutations.
| Mutation | Alignment position | Score | Adjusted incidence | BLOSUM62 delta |
|---|---|---|---|---|
| W152C | 153 | 127.3998575 | 9.79998904 | 13 |
| L452R | 456 | 121.4137761 | 20.23562935 | 6 |
| N501Y | 505 | 85.02822072 | 10.62852759 | 8 |
| Y145* | 145 | 75.00904159 | 6.819003781 | 11 |
| E484K | 488 | 74.37119842 | 18.59279961 | 4 |
| S13I | 13 | 59.21420352 | 9.86903392 | 6 |
| P681R | 685 | 56.39980273 | 6.266644748 | 9 |
| T95I | 95 | 54.82820976 | 9.138034961 | 6 |
Original nucleotide sequences are directly from NCBI's Betacoronavirus database and are last updated here on 23 May 2021 UTC.
Moderna and Pfizer-BioNTech vaccine mRNA sequences by Dae-Eun Jeong et al., 2021.
Multiple sequence alignments produced solely using MAFFT.
BLOSUM62 JSON by @camillescott.