The resolution of conventional optical microscopes is limited by light diffraction to about 200nm. Several superresolution techniques have been recently developed to overcome this limit. Among them, SIM (structured illumination microscopy) is one of the most suited for biological imaging.
The open source hardware project openSIM is an add-on designed at the Laboratory for Bio- and Nano- Instrumentation (LBNI, EPFL) (https://www.epfl.ch/labs/lbni/) to upgrade conventional fluorescence microscopes for superresolution imaging. The openSIM is an open-source hardware project which has been designed specifically so that it can be built easily by other researchers using the documentation. Our goal is to reach labs worldwide and build a vibrant open-hardware community.
Here you can find a schematic of the general structure of the openSIM documentation
A detailed documentation with all the information to build and use the openSIM is provided on our openSIM webpage: https://opensim.notion.site/
All the files that need to be downloaded in order to assemble and operate the openSIM can be found in this repository. More information about the structure of this repository can be found in the README file in the download folder.