Add disease_profile module in donor_organism

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For which schema is a change/update being suggested?

I would like to request an update to the donor_organism.json schema.

What should the change/update be?

Add a new module named disease_profile that would record specific disease measurements, categories, and characteristics.

This update constitutes a major change to the schema(s) it affects.

What new field(s) need to be changed/added?

• copd_gold_stage
• copd_mmrc_grade
• copd_cat_score
• copd_gold_abe_assessment
• copd_phenotype
• copd_emphysema_percentage

Fields details

Field name: copd_gold_stage

• Field description: Indicating current GOLD stage (Global Initiative for Chronic Obstructive Lung Disease).
• Field type: integer
• Required: no
• Examples: 1; 2; 3; 4
• Enum: 1, 2, 3, 4

Field name: copd_mmrc_grade

• Field description: Indicate the Modified British Medical Research Council (mMRC) dyspnea scale grade.
• Field type: integer
• Required: no
• Examples: 0, 1; 2; 3; 4
• Enum: 0, 1, 2, 3, 4

Field name: copd_cat_score

• Field description: Indicate the COPD Assessment Test (CAT) score.
• Field type: integer
• Required: no
• Examples: 2; 5; 37

Field name: copd_gold_abe_assessment

• Field description: Indicate the Global Initiative for Chronic Obstructive Lung Disease (GOLD) A, B, C, D assessment group if available.
• Field type: string
• Required: no
• Examples: A; B; E
• Enum: A, B, E

Field name: copd_phenotype

• Field description: Indicate the COPD disease phenotype(s) of donor. Please indicate all applicable phenotypes of donor.
• Field type: array
• Required: no
• Examples: COPD with bronchitis; COPD with history of asthma; COPD with emphysema
• Enum: COPD not otherwise specified, COPD with emphysema, COPD with bronchitis, COPD with history of asthma, COPD with >300 eos in blood, COPD with allergy, COPD with Chronic Mucus Hypersecretion, COPD with frequent exacerbations

Field name: copd_emphysema_percentage

• Field description: Indicate the percentage of the lung that is affected by emphysema as judged based on non-invasive imaging, such as from a CT scan.
• Field type: number
• Required: no
• Examples: 30; 76; 92

Why is the change requested?

Lung bionetwork is interested in recording specific disease characteristics for the COPD donors in their Tier 2 metadata. Oral and Craniofacial as well has requested many fields to record the profile of Peri-implantitis, periodontitis, Sjögren's disease etc. For this reason we decided to group these fields in this specific module. Each field name will begin with the disease name or a shorten disease name.