/latch_wf_clipkit

workflow for launching ClipKIT on the Latch platform

Primary LanguagePython


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ClipKIT, the multiple sequence alignment trimming toolkit

About

ClipKIT is a fast and flexible alignment trimming tool that keeps phylogenetically informative sites and removes those that display characteristics poor phylogenetic signal.


If you found clipkit useful, please cite ClipKIT: a multiple sequence alignment trimming software for accurate phylogenomic inference. Steenwyk et al. 2020, PLoS Biology. doi: 10.1371/journal.pbio.3001007.


Modes

Herein, we describe the various trimming modes implemented in ClipKIT. If you are unsure which is appropriate for you, we recommend using the default smart-gap trimming mode.


ClipKIT can be run with eight different modes, which are specified with the -m/–mode argument. Default: ‘smart-gap’

  • smart-gap: dynamic determination of gaps threshold
  • gappy: trim all sites that are above a threshold of gappyness (default: 0.9)
  • kpic: keep only parismony informative and constant sites
  • kpic-smart-gap: a combination of kpic- and smart-gap-based trimming
  • kpic-gappy: a combination of kpic- and gappy-based trimming
  • kpi: keep only parsimony informative sites
  • kpi-smart-gap: a combination of kpi- and smart-gap-based trimming
  • kpi-gappy: a combination of kpi- and gappy-based trimming