Can GraphST be applied for merfish?
Byronxy opened this issue · 1 comments
Byronxy commented
Dear developers,
Thanks for developing this great tool. Can I use this tool for processing merfish data and integrate scRNAseq data with merfish?
Rafael-Silva-Oliveira commented
From their paper "We designed GraphST to be user-friendly and capable of processing data acquired from different experimental platforms. GraphST has been validated on 10x Visium, Slide-seqV2, and Stereo-seq data, and we plan to extend it to other ST platforms, such as MERFISH and Nanostring CosMx SMI."
So I don't think so. Plus, the largest dataset they've tested had around 100k spots and the new VisiumHD at 8 micron resolution bin can have over 500k spots. So my guess is that GraphST is not yet capable of handling very big/granular datasets unfortunately.