LieberInstitute/spatialDLPFC

Replicate clinical enrichment results

lcolladotor opened this issue · 2 comments

We want to replicate the results from Figure 6 from the Nat Neuro paper. That will involve adapting this script Andrew wrote: https://github.com/LieberInstitute/HumanPilot/blob/master/Analysis/Layer_Guesses/check_clinical_gene_sets.R. I think that we had some supplementary figures that were also related to this, and if so, we'll want to replicate them too.

Screen Shot 2022-06-15 at 9 13 14 PM

If @kmartinow @kmaynard12 have other gene sets that they would like to check, we'll add them to the list. But first, let's replicate the results from before.

Thanks!

This is related to #79, although #79 is about choosing what example data to show on the shiny apps as well as making spatialLIBD more flexible so users (like you in this case) can choose what data is shown on the app.

  • @lcolladotor still waiting to finish this with the two gene sets that I can't load. We can talk about it in my meeting on Tuesday. See LieberInstitute/spatialLIBD#39
  • redo plots now that I fixed problem with two datasets
  • polish plots, fix plotting errors