CancerMIRNome
a web server for cancer miRNome interactive analysis and visualization
Please cite the following publication: Li, R., et al., CancerMIRNome: a web server for cancer miRNome interactive analysis and visualization
URL: http://bioinfo.jialab-ucr.org/CancerMIRNome/
IP Address: http://3.236.105.88:3838/CancerMIRNome/
Live Statistics: https://www.revolvermaps.com/livestats/map/59d9778kul4/
Introduction
miRNAs in cancer
MicroRNAs (miRNAs) are a class of small endogenous non-coding RNAs of ~22nt in length that negatively regulate the expression of their target protein-coding genes. miRNAs play critical roles in many biological processes, such as cell proliferation, differentiation, and apoptosis. miRNAs may function as oncogenes or tumor suppressors. Mounting evidences have demonstrated that the expression of miRNAs is dysregulated in various types of human cancers, which makes them potential biomarkers for cancer diagnosis and prognosis.
Circulating miRNAs as promising diagnostic biomarkers
miRNAs can be released into extracellular body fluids, including blood. Circulating miRNAs are incorporated in extracellular vesicles (EVs) such as shed microvesicles (sMVs) and exosomes, apoptotic bodies, or form complexes with RNA binding proteins such as Argonates (AGOs). The protected circulating miRNAs are remarkably stable in the extracellular environment, thus have tremendous potential as non-invasive diagnostic biomarkers for early cancer detection.
About CancerMIRNome
CancerMIRNome is a web server for cancer miRNome interactive analysis and visualization based on the huamn miRNome data of 33 cancer types from The Cancer Genome Atlas (TCGA), and 40 public cancer circulating miRNome profiling datasets from NCBI Gene Expression Omnibus (GEO) and ArrayExpress.
CancerMIRNome provides a user-friendly interface for miRNA analysis both at a single miRNA level to explore the expression and function of a miRNA in many different cancers and at a dataset level to identify diagnostic and prognostic biomarkers for a specific cancer type.
