Pinned Repositories
asymptoticMK
A web-based tool for estimating alpha, the fraction of nucleotide substitutions in a given genomic region that were driven to fixation by positive selection.
Chasing
Data and models for "Suppression gene drive in continuous space can result in unstable persistence of both drive and wild-type alleles"
cluster-guide
evolve-resequence-simulation
A customizable tool for simulation of evolve and resequence experiments on a quantitative trait
GeneDriveForSuppressionOfInvasiveRodents
Files and data to accompany "Modeling CRISPR gene drives for suppression of invasive rodents".
PerformanceOfAnophelesDriveCandidates
Models and data to accompany "Finding the strongest gene drive: Simulations reveal unexpected performance differences between Anopheles homing suppression drive candidates".
ResourceExplicitModels
Models and data for "Resource-Explicit Interaction Models for Spatial Populations"
SLiM
SLiM is a genetically explicit forward simulation software package for population genetics and evolutionary biology. It is highly flexible, with a built-in scripting language, and has a cross-platform graphical modeling environment called SLiMgui.
SLiM-Benchmarks
Benchmarking scripts to compare single-threaded and multi-threaded SLiM performance
SLiM-Extras
Extra add-ons that may be useful for people using SLiM, but that are not part of the SLiM project itself
Messer Lab's Repositories
MesserLab/SLiM
SLiM is a genetically explicit forward simulation software package for population genetics and evolutionary biology. It is highly flexible, with a built-in scripting language, and has a cross-platform graphical modeling environment called SLiMgui.
MesserLab/SLiM-Extras
Extra add-ons that may be useful for people using SLiM, but that are not part of the SLiM project itself
MesserLab/asymptoticMK
A web-based tool for estimating alpha, the fraction of nucleotide substitutions in a given genomic region that were driven to fixation by positive selection.
MesserLab/ResourceExplicitModels
Models and data for "Resource-Explicit Interaction Models for Spatial Populations"
MesserLab/GeneDriveForSuppressionOfInvasiveRodents
Files and data to accompany "Modeling CRISPR gene drives for suppression of invasive rodents".
MesserLab/Chasing
Data and models for "Suppression gene drive in continuous space can result in unstable persistence of both drive and wild-type alleles"
MesserLab/cluster-guide
MesserLab/evolve-resequence-simulation
A customizable tool for simulation of evolve and resequence experiments on a quantitative trait
MesserLab/PerformanceOfAnophelesDriveCandidates
Models and data to accompany "Finding the strongest gene drive: Simulations reveal unexpected performance differences between Anopheles homing suppression drive candidates".
MesserLab/SLiM-Benchmarks
Benchmarking scripts to compare single-threaded and multi-threaded SLiM performance
MesserLab/CRISPR-Cas9-fitness-effects
Files and data to accompany "Fitness effects of CRISPR endonucleases in D. melanogaster populations"
MesserLab/ResistanceInGeneDrives
MesserLab/TA-Underdominance-Drives
Models and data for "Design and analysis of CRISPR-based underdominance toxin-antidote gene drives."
MesserLab/Binomial-Analysis
A tool for performing binomial analysis to detect batch effects
MesserLab/GeneDriveForRodentControl
Files and data to accompany "Modeling the potential of CRISPR gene drives for rodent management".
MesserLab/HaplolethalHomingDrive
Files associated with "A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population".
MesserLab/Homing_Mechanisms_with_multiplexed_gRNAs
Data and models for "Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs"
MesserLab/HomingSuppressionDrive
Data and code for "A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles."
MesserLab/SLiM-Tests
Additional tests for SLiM validation and performance evaluation
MesserLab/TetheredDrives
Data and code for "Experimental demonstration of tethered gene drive systems for confined population modification or suppression."
MesserLab/ToxinAntidoteSystems
Data and code for "Performance analysis of novel toxin-antidote CRISPR gene drive systems"
MesserLab/UnderdominanceGeneDriveSystems
Models and data for "Population dynamics of underdominance gene drive systems in continuous space."