<html> <p>Model files in the NEURON simulation environment (v.8.2.0) from the paper:</p> <p><b>"Kinetics and functional consequences of BK channels activation by N-type Ca2+ channels in the dendrite of mouse neocortical layer-5 pyramidal neurons.”</b></p> <p>By Blömer LA, Giacalone E, Abbas F, Filipis L, Tegolo D, Migliore M and Canepari M</p> <p>Front. Cell. Neurosci. 18:1353895. doi: 10.3389/fncel.2024.1353895</p> <p></p> <p>Compile the mod files with mknrndll (mswin or graphical mac) or nrnivmodl (unix/linux)). Start the simulation by (unix/linux) typing on the command line:</p> <p>nrngui mosinit.hoc</p> <p>or (mac os x) drag and dropping the mosinit.hoc file on the nrngui icon or (mswin) double clicking on the mosinit.hoc file.</p> <p><br/> <br/> </p> <p> Click on the buttons "ctrl vs CaN block," "ctrl vs BK block," and "ctrl vs BK block vs & BK/CaN block" to replicate respectively the simulations shown in the left, center, and right panels of Figure 8B. Next, modify the parameter "cancoeff_bk2" to 0 and repeat the aforementioned steps to reproduce the previous simulations but without coupling between N-type VGCCs and BK CAKCs, as shown in Figure 8C.</p> <p>The simulations will reproduce the effects of coupling between BK CAKCs and N-type VGCCs in a biophysically accurate model.</p> </html>
ModelDBRepository/2015410
Kinetics and functional consequences of BK Channels activation by N-type Ca2+ channels in the dendrite of mouse neocortical layer-5 pyramidal neurons (Blömer et al., 2024)
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