Kinetic NMDA receptor model --------------------------- Based on voltage-clamp recordings of NMDA receptor-mediated currents in nucleated patches of rat neocortical layer 5 pyramidal neurons (Kampa 2004), this model was fit with AxoGraph directly to experimental recordings in order to obtain the optimal values for the parameters. ------------------------------------------------------ Demo file shows the behaviour of a kinetic NMDA receptor model reproducing the data in figure 2 in Kampa et al (2004) J Physiol. ------------------------------------------------------ The NMDA receptor model uses realistic rates of magnesium block and its effects on channel desensitisation. Presynaptic transmitter release is necessary for glutamate binding to the receptor. ------------------------------------------------------ Kinetic model from Kampa et al (2004) Kinetics of Mg2+ unblock of NMDA receptors: implications for spike-timing dependent synaptic plasticity. In: J Physiol 556.2: pp 337–345. -------------------------------- Model written by Bjoern Kampa, Canberra, 2004