SetNvidiaSettings
This tool built with VS 2019 allow you to disable Threaded optimization using a single command line:
SetNvidiaSettings "Profile Name" "executable_name.exe" "Nice description of the profile"Downloads
If you can't download from link just download from the Release folder ;)
Credits
This executable was built upon subGlitch's answer in the following issue: Nvidia graphics driver causing noticeable frame stuttering
Nuri Yuri just made an exe out of that for the purpose of its own projects.
Note
You should be able to boot up a VS 2019 solution from this repository but it hasn't been tested...