MethBat will aggregate and analyze CpG methylation calls made from PacBio HiFi datasets. Key features include:
- Creation of a methylation profile for a collection of genomic regions (e.g., CpG islands)
- Creation of cohort / background profiles from a collection of methylation profiles
- Analysis of cohort profiles comparing sub-groups (e.g., case v. control, male v. female)
- Segmentation of the CpGs in a dataset into Methylated, Unmethylated, or ASM regions
Authors: Matt Holt, Chris Saunders
Please note that MethBat is still in early development. We are still tweaking the input / output file formats and making changes that can affect the behavior of the program.
MethBat does not currently have a pre-print or publication.
If you notice any missing features, bugs, or need assistance with analyzing the output of MethBat, please don't hesitate to open a GitHub issue.
MethBat is a pre-release software intended for research use only and not for use in diagnostic procedures. While efforts have been made to ensure that MethBat lives up to the quality that PacBio strives for, we make no warranty regarding this software.
As MethBat is not covered by any service level agreement or the like, please do not contact a PacBio Field Applications Scientists or PacBio Customer Service for assistance with any MethBat release. Please report all issues through GitHub instead. We make no warranty that any such issue will be addressed, to any extent or within any time frame.
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