In bacteria, engineered short RNAs (sRNAs) are powerful tools for studying gene function. Using engineered sRNAs, researchers can tunably knock down the expression of a specific target gene, so as to determine the effects of that gene’s loss. This is particularly useful when studying genes that are essential for survival, which cannot be knocked out using traditional techniques. The purpose of this project, lead by Prof. Alex Wong from the Department of Biology, will be to create software to design sRNAs targeting user specified genes, using genome sequence information as input.
The Research Software Development team will support this research by implementing the sRNA design algorithms selected by Prof. Wong into a tool usable by researchers on the command line as well as through a web interface. Technologies to be used include: Python (including the Biopython library).
In the project directory, you can run:
Runs the app in the development mode.
Open http://localhost:3000 to view it in the browser.
The page will reload if you make edits.
You will also see any lint errors in the console.
Launches the test runner in the interactive watch mode.
See the section about running tests for more information.
Builds the app for production to the build folder.
It correctly bundles React in production mode and optimizes the build for the best performance.
The build is minified and the filenames include the hashes.
Your app is ready to be deployed!
See the section about deployment for more information.
Note: this is a one-way operation. Once you eject, you can’t go back!
If you aren’t satisfied with the build tool and configuration choices, you can eject at any time. This command will remove the single build dependency from your project.
Instead, it will copy all the configuration files and the transitive dependencies (Webpack, Babel, ESLint, etc) right into your project so you have full control over them. All of the commands except eject will still work, but they will point to the copied scripts so you can tweak them. At this point you’re on your own.
You don’t have to ever use eject. The curated feature set is suitable for small and middle deployments, and you shouldn’t feel obligated to use this feature. However we understand that this tool wouldn’t be useful if you couldn’t customize it when you are ready for it.