Schork-Lab/mediator-was

Compare NTR, MET, YFS, and Predixcan

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Compare the differences in weights learned by the different methods for two studies

  • How much do the beta's for a target snp differ?
    -- Relative to a gene's overall expression?
    -- Does this position have high LD with another position? Colinearity?
  • Quantify the differences in predicted expression
    -- Does using each method separately still control type I error?
  • How do their predictions differ from GTEX Blup estimates?
    -- Should you be matching on genetic background initially?
    -- Is one method consistently better for all genes?