QTL/TWAS analyses and related data of the manuscript "New insights into the genetic etiology of Alzheimer’s disease and related dementias" by Bellenguez, Küçükali, et al. Nature Genetics 2022.
Publication link: https://www.nature.com/articles/s41588-022-01024-z
For details, please see the publication. For any questions, please contact Fahri Küçükali (fahri.kucukali@uantwerpen.vib.be) and Kristel Sleegers (Kristel.Sleegers@uantwerpen.vib.be), or open a GitHub issue on this repository.
The significant eQTLs mapped and eTWAS functional reference panel weights generated for this study (in AD-relevant bulk brain regions from AMP-AD cohorts and in LCLs from the EADB Belgian cohort) are publicly available at https://doi.org/10.5281/zenodo.5745927.
The significant sQTLs mapped and sTWAS functional reference panel weights generated for this study (in AD-relevant bulk brain regions from AMP-AD cohorts and in LCLs from the EADB Belgian cohort) are publicly available at https://doi.org/10.5281/zenodo.5745929.
Anonymized aligned reads of the amplicon-based long-read nanopore cDNA sequencing experiment conducted for the TSPAN14 splicing analysis are available through ENA under accession PRJEB49234 (https://www.ebi.ac.uk/ena/browser/view/PRJEB49234).