/TCA

Identifying age-specific gene signatures for cerebral cortex with connectome-transcriptome correlation analysis

Primary LanguageR

TCA

Identifying age-specific gene signatures of the human cerebral cortex with joint analysis of transcriptomes and functional connectomes Here we present a method, TCA (Transcriptome- Connectome correlation Analysis), to identify gene signatures associated with cortex development and functionality across lifespan

List of files

  • Below the statistic folder are the intermediate statistical results generated, including enrichment analysis, regulatory networks, differentially expressed genes, etc.
  • the R script of getStablegene.R is the method to get the stable gene that are stable expressed in each age group.
  • the R script of networkBuild.R is the TCA algorithm to process the gene expression file, and get the ASC gene(Target Gene)
  • Below the diseaseRiskPos folder is the risk positions of different psychiatric disorders