WGLab/InterVar

Replace gnomad_genome with gnomad211_genome?

Opened this issue · 1 comments

Hi, I've downloaded gnomad211_genome.txt and gnomad211_genome.txt.idx from annovar and put it into the humandb folder. How can I enable InterVar to annotate variants based on gnomad211_genome rather than gnomad_genome? Is it correct to replace all the terms of "gnomad_genome" with "gnomad211_genome" in Intervar.py? After doing this, almost all the variants were annotated with BA=1 and BS1=1. Or should I just change gnomad_genome with gnomad211_genome in config.ini?

gnomad_genome is a database updated in 2017, and gnomad211_genome is updated in 2019, the difference between the two is relatively large. I don't think a direct replacement is appropriate and expect the author to update the InterVar version suitable for gnomad211_genome.