MYTH

A novel algorithm to score Methylation-Yielding Tumor Heterogeneity.

Description

The package is used to calculate IntraTumor Heterogeneity (ITH) based on alterations of DNA methylation profiles.

Installation

You can install the released version of MYTH with:

if (!requireNamespace("devtools", quietly = TRUE))
    install.packages("devtools")
devtools::install_github("WangX-Lab/MYTH/MYTH")

Examples

library(MYTH)
path <- system.file("extdata", "example_MYTH.txt", package = "MYTH", mustWork = TRUE)
input_data_met <- read.table(path, stringsAsFactors = FALSE, sep = "\t", header = TRUE, quote = "", row.names = 1)
MYTH(input_data_met)

Citation

Liu Q, Li L, Wang X. MYTH: An algorithm to score intratumour heterogeneity based on alterations of DNA methylation profiles. Clin Transl Med. 2021 Oct;11(10):e611. doi: 10.1002/ctm2.611. PMID: 34709741.