Subclass_specific_agents_for_HCC

Code accompanying the 'Exploring subclass-specific therapeutic agents for hepatocellular carcinoma by informatics guided drug screen' paper

All data used in this study are publicly available. RNA-seq data of LIHC are available through TCGA website (https://portal.gdc.cancer.gov/repository). RNA-seq data of LIRI cohort are available through ICGC portal (https://dcc.icgc.org/projects/LIRI-JP). RNA-seq data of CHCC cohort are available through NODE database (https://www.biosino.org/node). The data of GSE14520 and GSE76427 are downloaded from GEO (http://www.ncbi.nlm.nih.gov/geo/). The drug response data of CCLs are available through CTRP (v.2.0, released October 2015, https://portals.broadinstitute.org/ctrp), GDSC (GDSC1&2, released October 2019, https://www.cancerrxgene.org/), and PRISM Repurposing dataset (19Q4, released December 2019, https://depmap.org/portal/prism/).