SigMod is an exact and efficient method for identifying strongly interconnected disease-associated modules in gene (protein) network. SigMod is currently implemented in R.
The following plot gives an example of asthma-associated modules identified by SigMod using STRING network and GWAS outcomes:
- For description of the method and how to use the code, refer to SigMod_manual.pdf
- Example use of code in a general setting SigMod_example_code
- Example use of code using PINA interaction network SigMod_example_PINA
- Example use of code using STRING interaction network SigMod_example_STRING
If you use SigMod in your work, please cite: https://pubmed.ncbi.nlm.nih.gov/28069594/
- Author: Yuanlong LIU
- Affiliation: Computational Systems Oncology lab, Department of Computational Biology, University of Lausanne (http://ciriellolab.org/)
- Email: yliueagle@gmail.com