/Pediatric_Qualification_Package_CYP3A4_Ontogeny

Pediatric Qualification Package for CYP3A4 Ontogeny

Primary LanguageMATLAB

Pediatric Qualification Package for CYP3A4 Ontogeny

In this repository the electronic package for qualification of CYP3A4 ontogeny using in vivo probe substances are stored, including

  • Input files

For the Qualification of the CYP3A4 mediated elimination of compounds, the following probe substances were included:

  • Alfentanil [1]
  • Sufentanil [2]

Necessary software to execute the qualification workflow (see http://setup.open-systems-pharmacology.org for download links and instructions):

  • QualificationRunner
  • Reporting-Engine
  • Markdown-joiner

References

[1] Alfentanil-Model, Whole-body PBPK model of Alfentanil.

[2] Sufentanil-Model, Whole-body PBPK model of Sufentanil.