There are two major components of the NAGM framework: a module for the construction of a structure-guided network based on chemical modification (Fig. 1A) and an “overlap” algorithm that integrates RNA-Seq data with the comprehensive network to identify high-priority candidate genes (Fig. 1B).
Fig. 1. Workflow of the construction of structure-guided network and candidate genes screening.
A: The workflow of the construction of structure-guided network.
B: The workflow of candidate genes screening for each reaction in the structure-guided network.