/Systems-Biology-Project

Repository for the Systems Biology course project. Semester 2, 2019-20 by Professor Shaunak Sen

Primary LanguageMATLAB

Is the LacI-AraC dual feedback oscillator robust?

The work is aimed at reproducing and doing some analysis on the paper "Engineered temperature compensation in a synthetic genetic clock", https://www.pnas.org/content/111/3/972 We make a computational model of the dual feedback, synthetic oscillator and through analysis of different parameters, find whether the oscillator is robust or not.

Project slides can be found here https://docs.google.com/presentation/d/1MgishkrwRLeSKiKDlF3Q9XykfbC2XCCMUHLu8hH16SY/edit#slide=id.g946a6d2c72_0_199 Here are some pictures(from the slides only):

Variation of Time period of the oscillator with a particular parameter:

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Differential Equations that the oscillator follows(Hussain et.al, PNAS 2014):

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The computational simulation gives the following oscillations:

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