simplectf is a python program that estimates Contrast Transfer Function (CTF) parameters from aligned mrc files.
$ python3 -m pip install simplectf
$ simplectf --pixelsize 0.87 --voltage 200 --cs 2.7 image.mrc
creating ctf model
searching for optimal values
preprocessing time: 1.43
search time: 3.32
total time: 4.75
defocus values: 1.0806, 1.0701 microns
astigmatism angle: -0.00 degrees
phase shift: 0.00 degrees
cross correlation: 0.141275