Semmi is your assistant for WSJT-X (the extremely popular amateur radio weak-signal digital modes program).
This (experimental) helper program has limited automation features, for those operators who prefer a manual approach to FT8, and also appreciate useful decision support.
Download 
and run Semmi.msi (above) to install: https://github.com/avantol/Semmi/blob/main/Semmi.msi
At the Windows warning message, click "More info" then "Run anyway".
Use all appropriate caution since transmit can start at any time once you select "Enable auto-reply"!!! Whenever the "Enable auto-reply" button is green, your antenna can be energized.
Semmi runs alongside your existing version of WSJT-X (must use Windows 10 or later for reliability).
As a start, Semmi stores up "new" CQs (not worked before) that are interesting to you, and allows you to reply to each CQ, either manually or automatically:
You can also do things like:
- reply automatically to new CQs from local and/or DX stations
- reply automatically to new CQs from POTA stations
- reply automatically to new CQs directed to your state or country
- reply automatically to new CQs for the current band and/or mode
- reply automatically to CQs from new countries (and/or new for the current band)
- reply automatically to CQs from any countries you worked but have not QSL'd yet
- view all stored CQ details: country, continent, distance, SNR, and azimuth
- have much more time to research callers on QRZ, PSKReporter, and LOTW...
Note: Semmi is a bit fussy about the WSJT-X configuration, and will let you know what to watch out for.
If it's all a bit too much for you, use "Otto", which is much better integrated with (a modified) WSJT-X, and with many more helpful features.