/methInheritSim

Whole-Genome Inherited Bisulphite Sequencing Data Simulation

Primary LanguageR

Build Status codecov License: Artistic-2.0

Whole-Genome Inherited Bisulphite Sequencing Data Simulation

The methInheritSim package generates simulated multigenerational DMS datasets that are useful to evaluate the power and the false discovery rate of experiment design analysis, such as the methylInheritance methylInheritance package does. The multigenerational DMS datasets can also be used to compare the efficiency of different inheritance detection software.

Citing

If you use this package for a publication, we would ask you to cite the following:

Pascal Belleau, Astrid Deschênes, Marie-Pier Scott-Boyer, Romain Lambrot, Mathieu Dalvai, Sarah Kimmins, Janice Bailey, Arnaud Droit; Inferring and modeling inheritance of differentially methylated changes across multiple generations, Nucleic Acids Research, Volume 46, Issue 14, 21 August 2018, Pages e85. DOI: https://doi.org/10.1093/nar/gky362

Bioconductor Package

Bioconductor Time

methInheritSim is now an official package of Bioconductor. The current release can be directly downloaded from their website: Current release

Description of Package Functionality

The vignette of the methInheritSim package, which is a document that provides a task-oriented description of the package functionality, is available on Bioconductor website: methInheritSim vignette

Authors

Pascal Belleau, Astrid Deschênes and Arnaud Droit.

See Arnaud Droit Lab website.

Maintainer

Pascal Belleau

License

This package and the underlying methInheritSim code are distributed under the Artistic license 2.0. You are free to use and redistribute this software.

For more information on Artistic 2.0 License see http://opensource.org/licenses/Artistic-2.0

Bugs/Feature requests

If you have any bugs or feature requests, let us know.

Thanks!