/gpcr-signaling-simulation

Primary LanguageJupyter NotebookGNU General Public License v3.0GPL-3.0

ODE based simulation of GPCR signalling

This code accompanies the paper: Receptor endocytosis orchestrates the spatiotemporal bias in β-arrestin signaling.

It contains the following files:

  • code/model_vectorised.py: running the simulations
  • model/toth_szalai_gpcr.txt: the concentraions and reaction constants for ODE models
  • code/00-model_tutorial.ipynb: some tutorial
  • code/01-run_models.ipynb: code to run the simulations in the paper
  • code/02-figures.ipynb: code to reproduce the figures of the paper

Model