This is how I have it set up on my MacBook.
The below is the content of my /Library/LaunchDaemons/is.bep.dns.plist file. I have a nogo.db file in ~/config/nogo and the nogo binary in ~/go/bin. You obviously need to change the paths to your liking.
<!DOCTYPE plist PUBLIC -//Apple Computer//DTD PLIST 1.0//EN http://www.apple.com/DTDs/PropertyList-1.0.dtd >
<plist version="1.0">
<dict>
<key>Label</key>
<string>com.is.dns</string>
<key>ProgramArguments</key>
<array>
<string>/Users/bep/go/bin/nogo</string>
<string>-web-addr</string>
<string>:8123</string>
<string>-dns-proxyto</string>
<string>1.1.1.1:53,8.8.8.8:53,8.8.4.4:53</string>
<string>-db</string>
<string>/Users/bep/config/nogo/nogo.db</string>
</array>
<key>KeepAlive</key>
<true/>
<key>RunAtLoad</key>
<true/>
<key>StandardOutPath</key>
<string>/var/log/nogo.log</string>
<key>StandardErrorPath</key>
<string>/var/log/nogo.log</string>
</dict>
</plist>