The goal of reportRmd is to automate the reporting of clinical data in Rmarkdown environments. Functions include table one-style summary statistics, compilation of multiple univariate models, tidy output of multivariable models and side by side comparisons of univariate and multivariable models. Plotting functions include customisable survival curves, forest plots, and automated bivariate plots.
Installing from CRAN:
install.packages('reportRmd')You can install the development version of reportRmd from GitHub with:
# install.packages("devtools")
devtools::install_github("biostatsPMH/reportRmd", ref="development")- Survival curves have been improved and now return ggplots
- Variable labels will now be automatically output in tables
library(reportRmd)
data("pembrolizumab")
rm_covsum(data=pembrolizumab, maincov = 'sex',
covs=c('age','pdl1','change_ctdna_group'),
show.tests=TRUE)| Full Sample (n=94) | Female (n=58) | Male (n=36) | p-value | StatTest | |
|---|---|---|---|---|---|
| age | 0.30 | Wilcoxon Rank Sum | |||
| Mean (sd) | 57.9 (12.8) | 56.9 (12.6) | 59.3 (13.1) | ||
| Median (Min,Max) | 59.1 (21.1, 81.8) | 56.6 (34.1, 78.2) | 61.2 (21.1, 81.8) | ||
| pdl1 | 0.76 | Wilcoxon Rank Sum | |||
| Mean (sd) | 13.9 (29.2) | 15.0 (30.5) | 12.1 (27.3) | ||
| Median (Min,Max) | 0 (0, 100) | 0.5 (0.0, 100.0) | 0 (0, 100) | ||
| Missing | 1 | 0 | 1 | ||
| change ctdna group | 0.84 | Chi Sq | |||
| Decrease from baseline | 33 (45) | 19 (48) | 14 (42) | ||
| Increase from baseline | 40 (55) | 21 (52) | 19 (58) | ||
| Missing | 21 | 18 | 3 |
var_names <- data.frame(var=c("age","pdl1","change_ctdna_group"),
label=c('Age at study entry',
'PD L1 percent',
'ctDNA change from baseline to cycle 3'))
pembrolizumab <- set_labels(pembrolizumab,var_names)
rm_covsum(data=pembrolizumab, maincov = 'sex',
covs=c('age','pdl1','change_ctdna_group'))| Full Sample (n=94) | Female (n=58) | Male (n=36) | p-value | |
|---|---|---|---|---|
| Age at study entry | 0.30 | |||
| Mean (sd) | 57.9 (12.8) | 56.9 (12.6) | 59.3 (13.1) | |
| Median (Min,Max) | 59.1 (21.1, 81.8) | 56.6 (34.1, 78.2) | 61.2 (21.1, 81.8) | |
| PD L1 percent | 0.76 | |||
| Mean (sd) | 13.9 (29.2) | 15.0 (30.5) | 12.1 (27.3) | |
| Median (Min,Max) | 0 (0, 100) | 0.5 (0.0, 100.0) | 0 (0, 100) | |
| Missing | 1 | 0 | 1 | |
| ctDNA change from baseline to cycle 3 | 0.84 | |||
| Decrease from baseline | 33 (45) | 19 (48) | 14 (42) | |
| Increase from baseline | 40 (55) | 21 (52) | 19 (58) | |
| Missing | 21 | 18 | 3 |
rm_uvsum(data=pembrolizumab, response='orr',
covs=c('age','pdl1','change_ctdna_group'))
#> Waiting for profiling to be done...
#> Waiting for profiling to be done...
#> Waiting for profiling to be done...| OR(95%CI) | p-value | N | Event | |
|---|---|---|---|---|
| Age at study entry | 0.96 (0.91, 1.00) | 0.089 | 94 | 78 |
| PD L1 percent | 0.97 (0.95, 0.98) | \<0.001 | 93 | 77 |
| ctDNA change from baseline to cycle 3 | 0.002 | 73 | 58 | |
| Decrease from baseline | Reference | 33 | 19 | |
| Increase from baseline | 28.74 (5.20, 540.18) | 40 | 39 |
glm_fit <- glm(orr~change_ctdna_group+pdl1+cohort,
family='binomial',
data = pembrolizumab)
rm_mvsum(glm_fit,showN=T)| OR(95%CI) | p-value | N | Event | VIF | |
|---|---|---|---|---|---|
| ctDNA change from baseline to cycle 3 | 0.009 | 73 | 58 | 1.00 | |
| Decrease from baseline | Reference | 33 | 19 | ||
| Increase from baseline | 19.99 (2.08, 191.60) | 40 | 39 | ||
| PD L1 percent | 0.97 (0.95, 1.00) | 0.066 | 73 | 58 | 1.18 |
| cohort | 0.004 | 73 | 58 | 1.04 | |
| A | Reference | 14 | 11 | ||
| B | 2.6e+07 (0e+00, Inf) | 1.00 | 11 | 11 | |
| C | 4.2e+07 (0e+00, Inf) | 1.00 | 10 | 10 | |
| D | 0.07 (4.2e-03, 1.09) | 0.057 | 10 | 3 | |
| E | 0.44 (0.04, 5.10) | 0.51 | 28 | 23 |
uvsumTable <- rm_uvsum(data=pembrolizumab, response='orr',
covs=c('age','sex','pdl1','change_ctdna_group'),tableOnly = TRUE)
#> Waiting for profiling to be done...
#> Waiting for profiling to be done...
#> Waiting for profiling to be done...
#> Waiting for profiling to be done...
glm_fit <- glm(orr~change_ctdna_group+pdl1,
family='binomial',
data = pembrolizumab)
mvsumTable <- rm_mvsum(glm_fit,tableOnly = TRUE)
rm_uv_mv(uvsumTable,mvsumTable)| Unadjusted OR(95%CI) | p | Adjusted OR(95%CI) | p (adj) | |
|---|---|---|---|---|
| Age at study entry | 0.96 (0.91, 1.00) | 0.089 | ||
| sex | 0.11 | |||
| Female | Reference | |||
| Male | 0.41 (0.13, 1.22) | |||
| PD L1 percent | 0.97 (0.95, 0.98) | \<0.001 | 0.98 (0.96, 1.00) | 0.024 |
| ctDNA change from baseline to cycle 3 | 0.002 | 0.004 | ||
| Decrease from baseline | Reference | Reference | ||
| Increase from baseline | 28.74 (5.20, 540.18) | 24.71 (2.87, 212.70) |
Shows events, median survival, survival rates at different times and the log rank test. Does not allow for covariates or strata, just simple tests between groups
rm_survsum(data=pembrolizumab,time='os_time',status='os_status',
group="cohort",survtimes=c(12,24),
# group="cohort",survtimes=seq(12,36,12),
# survtimesLbls=seq(1,3,1),
survtimesLbls=c(1,2),
survtimeunit='yr')| Group | Events/Total | Median (95%CI) | 1yr (95% CI) | 2yr (95% CI) |
|---|---|---|---|---|
| A | 12/16 | 8.30 (4.24, NA) | 0.38 (0.20, 0.71) | 0.23 (0.09, 0.59) |
| B | 16/18 | 8.82 (4.67, 20.73) | 0.32 (0.16, 0.64) | 0.06 (9.6e-03, 0.42) |
| C | 12/18 | 17.56 (7.95, NA) | 0.61 (0.42, 0.88) | 0.44 (0.27, 0.74) |
| D | 4/12 | NA (6.44, NA) | 0.67 (0.45, 0.99) | 0.67 (0.45, 0.99) |
| E | 20/30 | 14.26 (9.69, NA) | 0.63 (0.48, 0.83) | 0.34 (0.20, 0.57) |
| Log Rank Test | ChiSq | 11.3 on 4 df | ||
| p-value | 0.023 |
library(survival)
data(pbc)
rm_cifsum(data=pbc,time='time',status='status',group=c('trt','sex'),
eventtimes=c(1825,3650),eventtimeunit='day')
#> 106 observations with missing data were removed.| Strata | Event/Total | 1825day (95% CI) | 3650day (95% CI) |
|---|---|---|---|
| 1, f | 7/137 | 0.04 (0.01, 0.08) | 0.06 (0.03, 0.12) |
| 1, m | 3/21 | 0.10 (0.02, 0.27) | 0.16 (0.03, 0.36) |
| 2, f | 9/139 | 0.05 (0.02, 0.09) | 0.09 (0.04, 0.17) |
| 2, m | 0/15 | 0e+00 (NA, NA) | 0e+00 (NA, NA) |
| Gray’s Test | ChiSq | 3.3 on 3 df | |
| p-value | 0.35 |
ggkmcif2(response = c('os_time','os_status'),
cov='cohort',
data=pembrolizumab)
require(ggplot2)
#> Loading required package: ggplot2
forestplot2(glm_fit)
#> Warning: `forestplot2()` was deprecated in reportRmd 0.1.0.
#> ℹ Please use `forestplotUV()` instead.
#> This warning is displayed once every 8 hours.
#> Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
#> generated.
#> Warning: Vectorized input to `element_text()` is not officially supported.
#> ℹ Results may be unexpected or may change in future versions of ggplot2.
These plots are designed for quick inspection of many variables, not for publication.
require(ggplot2)
plotuv(data=pembrolizumab, response='orr',
covs=c('age','cohort','pdl1','change_ctdna_group'))
#> Boxplots not shown for categories with fewer than 20 observations.
#> Boxplots not shown for categories with fewer than 20 observations.