<html><pre> Reproduces all simulations from: Steephen, J. E., & Manchanda, R. (2009). Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents. J Comput Neurosci doi:10.1007/s10827-009-0161-7 This implementation by John Eric Steephen (johneric@iitb.ac.in) to whom questions should be addressed. Usage: Auto-launch from ModelDB and skip to step 4 or 1. Unzip MSN2009.zip into an empty directory. 2. Compile the mod files with mknrndll (or nrnivmodl in unix). 3. Double click on main.hoc (or drag and drop onto nrngui (MAC), or start with "nrngui main.hoc" (unix/linux)). 4. A window with the title Control Panel will appear with several controls, one of which will be the "Help" button. Click the "Help" button to see instructions on how to reproduce the simulations described in the paper. Example: After right clicking on the graph and selecting "Keep lines" follow the instructions in the "Help" panel to recreate figure 1B from the paper: <img src="./fig1b.jpg" alt="Figure 1B"> 20111102 Files chan_Cadyn.mod chan_CaN.mod updated to use derivimplicit. See http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592 for more. 20120201 chan_CaKdyn.mod chan_CaL12.mod chan_CaL13.mod chan_CaQ.mod chan_CaR.mod chan_CaT.mod also updated to not use euler (see above link to neuron forum). </pre></html>
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Effects of KIR current inactivation in NAc Medium Spiny Neurons (Steephen and Manchanda 2009)
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