/******Cerebellar Cortex with Gap Junctions between Golgi cells******/ Developers: Fabio M Simoes de Souza & E De Schutter Work Progress: Jan 2010 - Dec 2010 Developed At: Okinawa Institute of Science and Technology Computational Neuroscience Unit Okinawa - Japan Model Published in: Simoes de Souza FM and De Schutter E (2011) Robustness effect of gap junctions between Golgi cells on cerebellar cortex oscillations. Neural Systems & Circuits 1:7. Abstract Background: Previous one-dimensional network modeling of the cerebellar granular layer has been successfully linked with a range of cerebellar cortex oscillations observed in vivo. However, the recent discovery of gap junctions between Golgi cells (GoCs), which may cause oscillations by themselves, has raised the question of how gap-junction coupling affects GoC and granular-layer oscillations. To investigate this question, we developed a novel two-dimensional computational model of the GoC-granule cell (GC) circuit with and without gap junctions between GoCs.Results: Isolated GoCs coupled by gap junctions had a strong tendency to generate spontaneous oscillations without affecting their mean firing frequencies in response to distributed mossy fiber input. Conversely, when GoCs were synaptically connected in the granular layer, gap junctions increased the power of the oscillations, but the oscillations were primarily driven by the synaptic feedback loop between GoCs and GCs, and the gap junctions did not change oscillation frequency or the mean firing rate of either GoCs or GCs.Conclusion: Our modeling results suggest that gap junctions between GoCs increase the robustness of cerebellar cortex oscillations that are primarily driven by the feedback loop between GoCs and GCs. The robustness effect of gap junctions on synaptically driven oscillations observed in our model may be a general mechanism, also present in other regions of the brain. Usage instructions: Auto-launch from ModelDB or download and extract the archive. Then under: ---- MSWIN run mknrndll, cd to the archive and make the nrnmech.dll. Then double click on the mosinit.hoc file. ---- MAC OS X Drag and drop the network folder onto the mknrndll icon. Drag and drop the mosinit.hoc file onto the nrngui icon. ---- Linux/Unix Change directory to the network folder. run nrnivmodl. Then type nrngui mosinit.hoc ---- Uncomment the GJ flag on mosinit.hoc to select a network with or without GJ between GoCs. Once the simulation is started it will produce a result similar to figure 9 from Simoes de Souza and De Schutter 2011. Changelog ========= * 20220924: Update MOD files to avoid declaring variables and functions with the same name. See neuronsimulator/nrn#1992
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Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
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